A small study by investigators from Harvard University suggests that cryopreserved embryo transfer (CET) is a strong independent risk factor for placenta accreta in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).
A small study by investigators from Harvard University suggests that cryopreserved embryo transfer (CET) is a strong independent risk factor for placenta accreta in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). The findings, presented at the American Society for Reproductive Medicine 70th Annual Meeting, showed an even stronger association in cases of accreta with complications.
Data on 1,569 women who had delivered at least one viable infant at ≥24 weeks’ gestation and underwent a Day 3 or Day 5 transfer at a single institution between 2005 and 2011 were included in the analysis. Among them, 52 cases of placenta accreta were identified, as confirmed by histology or a clinical finding of an adherent placenta with or without morbid complications such as postpartum hemorrhage, hysterectomy or surgery to remove the placenta. Cases were matched 1:3 by maternal age and history of prior cesarean to IVF/ICSI patients without accreta.
Multivariate analysis resulted in an overall incidence of accreta in the cohort of 3.31% (52/1,569), versus 7.24% (16/221) in the women who had undergone CET. The median age of cases and controls was similar (39.3 versus 39.1). No potential confounders were included in the final model because none were found to change the effect size for CET by more than 10%.
Feature: Euploid single-embryo transfer: The new IVF paradigm
The only significant predictors of accreta were CET (P=.04), prior myomectomy (P<.01), and placenta previa (P<.0001). When the analysis was restricted to only morbid cases of accreta, the effect was strengthened to 2.78 (95% CI 1.11-6.99; P=.03).
To get weekly advice for today's Ob/Gyn, subscribe to the Contemporary OB/GYN Special Delivery.
S4E1: New RNA platform can predict pregnancy complications
February 11th 2022In this episode of Pap Talk, Contemporary OB/GYN® sat down with Maneesh Jain, CEO of Mirvie, and Michal Elovitz, MD, chief medical advisor at Mirvie, a new RNA platform that is able to predict pregnancy complications by revealing the biology of each pregnancy. They discussed recently published data regarding the platform's ability to predict preeclampsia and preterm birth.
Listen
Adverse maternal outcomes after uterine conservation in placenta accreta spectrum
May 9th 2024A review of 5 studies reveals a significant 1 in 4 incidence of adverse maternal outcomes following uterine conservation in patients with placenta accreta spectrum, underlining the importance of expert multidisciplinary care.
Read More
Pioglitazone outperforms metformin in IVF for PCOS-related infertility
May 6th 2024A recent double-blind, randomized clinical trial revealed a higher clinical pregnancy rate with pioglitazone compared to metformin in polycystic ovarian syndrome patients undergoing in vitro fertilization, suggesting potential for improved outcomes.
Read More