Top 5 Contemporary OB/GYN articles of 2024
Find out which articles were the most popular during 2024.
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Thank you for visiting the Contemporary OB/GYN website throughout 2024. Below, take a look at the top stories published this year, and catch up on anything you may have missed.
1. FDA warns of false positive HSV-2 test risks
In January 2024, the FDA reminded health care providers and clinical laboratory staff about the risk of false positive genital herpes simplex virus type 2 (HSV-2) serological test results.
To reduce the risk of a false positive HSV-2 serological test result, the FDA provided information on risk factors and recommendations for health care providers and clinical laboratory staff. Additionally, the FDA has stated it will provide new information as it becomes available.
According to the FDA, health care providers and clinical laboratory staff should review CDC guidelines prior to ordering HSV-2 serological testing and to be aware of the chances for a false positive result. Providers should also counsel patients about testing limitations before testing, and results should undergo performative testing in accordance with professional guidelines.
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2. Nighttime vasomotor symptoms linked to Alzheimer's risk
Nighttime vasomotor symptoms (VMS) may be an indicator of Alzheimer disease (AD) in women, according to a recent study published in the American Journal of Obstetrics & Gynecology.
Investigators conducted a study to evaluate the association between VMS and plasma-based biomarkers of AD. Participants included women aged 45 to 67 years with a uterus and at least 1 ovary who had late perimenopausal or postmenopausal status.
Patients underwent VMS monitoring for 3 days using a physiological VMS monitor and VMS diary. The VMS monitor measured sternal skin conductance to determine VMS. The VMS diary included self-reported date-and-time-stamped VMS. VMS was divided by monitoring time and standardized to a 24-hour day to determine VMS rates.
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3. Cesarean deliveries linked to reduced fecundability and increased infertility risk
Fecundability ratio is reduced among women with more than 1 child reporting a previous cesarean delivery (CD) vs vaginal delivery, while the risk of infertility is increased, according to a recent study published in the American Journal of Obstetrics & Gynecology.
Women with a prior CD had a lower fecundability ratio than those with prior vaginal delivery, with absolute infertility risks of 9.9% and 7.3%, respectively. This indicated a corresponding risk ratio of 1.21 for women with previous CD.
Similar results were reported when excluding women aged 35 years or older or pregnancies with a time to pregnancy of 3 or more months. Planned and emergency CDs also had similar fecundability patterns.
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4. Metformin during pregnancy not linked to adverse birth outcomes
Women who continue metformin therapy through pregnancy are at little increased risk of experiencing a nonlive birth versus women who switched from metformin to insulin monotherapy, according to new research.1
Data from a registry cohort analysis conducted by a team of Harvard-based investigators found that gestational metformin use—the first-line treatment for patients with type 2 diabetes (T2D)—may not be associated with a significant risk of either nonlive birth or congenital malformations among newborns. The findings are encouraging—not only relative to the increased prevalence of T2D and gestational diabetes among childbearing-age women but also to the utility of metformin in the management of polycystic ovary syndrome (PCOS) effects as well.2
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5. Adverse outcomes of hysterectomy with bilateral salpingo-oophorectomy
The addition of bilateral salpingo-oophorectomy (BSO) alongside hysterectomy is associated with multiple adverse outcomes, according to a study published in the American Journal of Obstetrics & Gynecology.
Investigators conducted a systematic review and meta-analysis to evaluate health outcomes of BSO with hysterectomy and reported associations. The PubMed, Web of Science, and Embase databases were searched for relevant literature published from January 2015 to August 2022.
Results of the study demonstrated a significant reduction in ovarian cancer risk following hysterectomy and BSO, with a hazard ratio (HR) of 0.11. Breast cancer risk was also decreased by hysterectomy with BSO compared to only hysterectomy or no surgery, with an HR of 0.78. This association was found in women aged under 45 years, but not 50 years or older.
