Gynecologic Oncology

A 2-dose quadrivalent human papillomavirus (HPV) vaccine series in girls may be as immunogenic as a 3-dose series, but there may be a loss of noninferiority to some genotypes after 2 years.

Authors of a new study identified four strategies for cervical cancer screening that maximize benefits while reducing the potential for harm.

A test for cervical cancer that uses ordinary vinegar--and that can be performed by trained laypersons--holds promise for poor countries where cytology-based screening is not easily implemented. This low-cost, innovative solution to a pressing women’s health problem was presented at the 2013 annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

A commentary on ACOG Practice Bulletin Number 131: Screening for Cervical Cancer, November 2012

The female hormone megestrol acetate (MA) improves appetite and is associated with slight weight gain in patients with cancer, AIDS, and other underlying pathology, but comes with significant adverse events.

Women with endometriosis who undergo surgery to treat the condition are less likely to have ovarian cancer develop later in life.

Patients with stage IVB, recurrent, or persistent cervical cancer that was not cured with standard treatment who were given the angiogenesis inhibitor bevacizumab lived 3.7 months longer than patients who did not receive the drug, but adverse events increased.

A meta-analysis of two Gynecologic Oncology Group (GOG) clinical trials shows a clear long-term survival benefit for intraperitoneal (IP) therapy over intravenous (IV) treatment of ovarian cancer. The results were presented at the 2013 Society of Gynecologic Oncology Annual Meeting on Women’s Cancer in Los Angeles.

The use of APTIMA human papillomavirus (AHPV) assay for the detection of high-risk human papillomavirus E6/E7 oncogenic messenger RNA is an effective triage method for colposcopy referral in women with atypical squamous cells of undetermined significance cytology (ASC-US).

From ASRM’s removal of the ‘experimental’ label from the procedure of oocyte cryopreservation, to discoveries into the complex genetic processes involved in ovarian cancer, 2012 was another important year in ob/gyn research. Here, the leaders of seven major ob/gyn societies reflect on the most exciting research of the last year.

Some may argue that the new ACOG, ACS and other cervical cancer screening guidelines will detect the majority of at-risk women. We should not be content with settling for identifying a majority of at risk women; rather, we should constantly reassess the availability of useful tests to see if we can improve reliability.

Nurse-delivered interventions that combined psychoeducation with supportive attention may help improve mood in patients in whom cancer has been newly diagnosed.

Using sophisticated gene sequencing methods, researchers at Yale School of Medicine have demonstrated a regulatory link between stem cell factors that fuel the growth of ovarian cancer and the prognosis of patients, according to a new report.

Human papillomavirus (HPV) vaccination may be beneficial for women with HIV infection even after previous exposure to HPV, according to the findings of a new study.

The effects of exercise during and after cancer treatment are different, according to the findings of a new systematic review. Researchers concluded that exercise has a palliative effect in patients during cancer treatment and a recuperative effect after treatment.

An intrauterine device (IUD) is an effective tool in the treatment of early-stage endometrial cancer in certain patients, according to the results of a small study presented at the International Gynecological Cancer Society’s 14th biennial meeting.

Neoadjuvant chemotherapy is a reasonable alternative to primary debulking surgery in women with stage IIIc/IV ovarian cancer, according to new intervention review.

A review comparing laparoscopic hysterectomy versus abdominal hysterectomy for early-stage endometrial cancer has found that rates of overall survival and disease-free survival are similar for the surgical procedures.

Researchers in France have developed a nomogram based on pathological hysterectomy characteristics to predict lymph node metastasis in patients with endometrial cancer.

In patients with heavily pretreated HER2-positive metastatic breast cancer, combination treatment with lapatinib and trastuzumab was associated with a median survival benefit of 4.5 months, according to the final results of a phase III study.

Postoperative use of a neoprene abdominal-pelvic binder significantly increases ambulatory events in the first 24 hours after surgery and may be of benefit particularly in a high-risk gynecological oncology surgical population, according to a study presented the American Congress of Obstetricians and Gynecologists’ Annual Clinical Meeting.

Laparoscopy has short-term advantages and seemingly equivalent long-term outcomes as compared with laparotomy for endometrial cancer according to a meta-analysis of randomized controlled trials.

Emerging information on the link between ovarian cancer and endometriosis gives us an unprecedented opportunity to develop comprehensive screening plans for early detection and prevention of specific types of ovarian cancer.

Human papillomavirus vaccines provide still some benefit to women who have undergone treatment for HPV-related diseases, according to a new study published in the British Medical Journal.

New screening guidelines for the prevention and early detection of cervical cancer are now largely based on the patient’s age, and testing for HPV DNA has now been incorporated into the screening process.

New screening guidelines for the prevention and early detection of cervical cancer are now largely based on the patient’s age and, for the first time, testing for human papillomavirus (HPV) DNA has been incorporated into the screening process.

Laparoscopic staging of uterine cancer is associated with only a small increased risk of recurrence, according to a new study in the Journal of Clinical Oncology.

Your patient just received devastating news: she has cancer. As treatment options and anxieties swirl, more and more women are now faced with another issue: how will the cancer and its treatment impact their fertility?

Two new studies published in the New England Journal of Medicine point to the importance of using bevacizumab in the treatment of ovarian cancer. Bevacizumab, a recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor, has shown single-agent activity in women with recurrent tumors.

With its implications of sexual transmission and potential cervical cancer, a diagnosis of genital warts can be emotionally distressing to patients. Because no single treatment serves every patient, the best approach to selecting a therapeutic option considers the extent of the disease, wart location, and the patient's individual needs.