Survival benefit in advanced or metastatic breast cancer with visceral metastases
June 12th 2020Findings from a new study show significant overall survival benefit of Novartis’ ribociclib in hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer with visceral metastases.
The Society for Maternal-Fetal Medicine consult series #49 on cesarean scar pregnancy
Cesarean scar pregnancy (CSP) is a complication in which an early pregnancy implants in the scar from a prior cesarean delivery. Incidence and recognition of this condition appear to have increased over the past two decades, perhaps due to high worldwide cesarean delivery rates. The clinical presentation is variable, and many women are asymptomatic at presentation. CSP can be difficult to diagnose in a timely fashion. Ultrasound is the primary imaging modality for CSP diagnosis. Expectantly managed CSP is associated with high rates of severe maternal morbidity such as hemorrhage, placenta accreta spectrum (PAS), and uterine rupture. Given these substantial risks, pregnancy termination is recommended after CSP diagnosis. Several surgical and medical treatments have been described for this disorder, but at this time, optimal management remains uncertain.
Legally Speaking: Did contraindicated hysterectomy lead to HIT and limb loss?
June 11th 2020The patient had a history of fibroid uterus and dilated pelvic vessels in the left adnexal region, obscuring the left ovary. On April 2, 2014, the patient was seen as a gyn outpatient at the clinic by Defendant OB. The patient complained it caused her urinary tract irritative symptoms and back pain. An MRI was ordered for evaluation. A 9.9cm exophytic fibroid arising from the posterior uterine body with focal cystic degeneration was seen.
Prepregnancy hemoglobin A1c and risk of maternal complications
June 10th 2020Canadian researchers say that prepregnancy elevated levels of hemoglobin A1C—even below thresholds for diabetes mellitus (DM)—may increase risk of severe maternal morbidity. The findings are from a population-based cohort study published in PLoS Medicine.
Study finds plasma oxytocin levels higher in OC users
June 10th 2020Plasma oxytocin levels are significantly higher in oral contraceptive (OC) users than in to non-users, according to a study in Scientific Reports. The cross-sectional study of nearly 200 women also found that scores for satisfaction with life were higher among OC users.
HIV and COVID-19: Pharmacists and Healthcare Systems Mitigate Risks
June 10th 2020Approximately 1.1 million people in the U.S. are living with HIV today. In the midst of the global COVID-19 pandemic, a lack of information exists about whether HIV patients are at an increased risk for contracting the virus.
Validation of the ultrasound-based endometriosis staging system
June 9th 2020An external validation multicenter international study, in the hands of expert ultrasound examiners, has concluded that the ultrasound-based endometriosis scoring system (UBESS) is accurate in predicting the level of surgical complexity in the presence of bowel deep endometriosis or obliterated pouch of Douglas.