Cervical Cancer with Human Papilloma Virus and Epstein Barr Virus Positive
The Early-7 (E7) protein of HPV binds to the underphosphorelated form of the tumor suppressor protein - pRb and displaces the E2F transcription factor that is normally bound by pRb. The latent membrane protein-1 (LMP-1) of EBV prevents apoptosis of B cells by up regulating the expression of bcl-2, and it activates growth promoting pathway that are normally triggered by T cell - derivate signal.
Journal of Carcinogenesis 2006, by BioMed Central
An open access article
Short paper
Published 10 May 2006
Abstract (provisional)
The Early-7 (E7) protein of HPV binds to the underphosphorelated form of the tumor suppressor protein - pRb and displaces the E2F transcription factor that is normally bound by pRb. The latent membrane protein-1 (LMP-1) of EBV prevents apoptosis of B cells by up regulating the expression of bcl-2, and it activates growth promoting pathway that are normally triggered by T cell - derivate signal. The aims of this study to know that in cervical cancer stay HPV and EBV. DNA was isolated from nineteen sample cervical cancer tissues frozen section. Diagnose related with HPV and EBV was made by Polymerase Chains Reaction (PCR). The result of this experiment showed that from 19 samples diagnosed as cervical cancer, 17 samples are positive HPV and 13 samples had HPV and EBV positive. The conclusion of this experiment is 89% of cervical cancers are infected with HPV and 68% also infected with HPV and EBV.
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