Opinion|Videos|December 2, 2024
Neurokinin and Estrogen Balance in Menopausal Hot Flashes for Primary Care
Panelists discuss how to simplify the physiology of KNDy neurons and neurokinin (NK) receptors for primary care physicians, explaining how NK3 antagonism reduces hot flashes, while NK1 antagonism helps alleviate sleep disturbances and night sweats, with fezolinetant and elinzanetant serving as key nonhormonal treatment options.
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Episodes in this series
- How can we simplify the physiology of KNDY neurons and roles of NK receptors for better understanding among primary care physicians?
Note: NK3 antagonism targets VMS (hot flashes); NK1 antagonism impacts sleep and night sweats
Note: Fezolinetant, a selective NK3 antagonist, reduces hot flashes
Note: Elinzanetant, in addition to reducing hot flashes (via NK3 antagonism) is also an NK1 antagonist which improves sleep disturbances and night sweats
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