Neurokinin and Estrogen Balance in Menopausal Hot Flashes for Primary Care

EP: 1.Overview of KNDy neurons

EP: 2.VMS Symptoms and Neurokinin Receptor Antagonists

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EP: 3.Neurokinin and Estrogen Balance in Menopausal Hot Flashes for Primary Care

EP: 4.Fezolinetant Guidelines and Emerging Data on Menopause and Liver Health

EP: 5.Molecular Comparison and Safety Profiles of Fezolinetant and Elinzanetant

EP: 6.Malignancy Risks of Neurokinin Receptor Antagonists

EP: 7.Guidance for PCPs: Streamlining Menopause Care

EP: 8.Nonestrogen Treatments for Menopause

EP: 9.VMS Treatment Guidelines

• How can we simplify the physiology of KNDY neurons and roles of NK receptors for better understanding among primary care physicians?

Note: NK3 antagonism targets VMS (hot flashes); NK1 antagonism impacts sleep and night sweats

Note: Fezolinetant, a selective NK3 antagonist, reduces hot flashes

Note: Elinzanetant, in addition to reducing hot flashes (via NK3 antagonism) is also an NK1 antagonist which improves sleep disturbances and night sweats